Panminerva medica
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MicroRNAs (miRNAs) are non-coding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate post-transcriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR‑503, an associate of the "canonical" miRNA-16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence to show that miR‑503 functions as a tumor suppressor gene through its effects on target genes that regulate cell proliferation, migration, and invasion in tumor cells. In this current assessment, we discuss the biology and tumor suppressor role of miR‑503 in different cancers and elaborate on its mechanism of action.
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Review Meta Analysis
Modified Glasgow prognostic score might be a prognostic factor for hepatocellular carcinoma: a meta-analysis.
Hepatocellular carcinoma (HCC) is the fifth-most common cancer. Recent studies have demonstrated that there was a relationship between modified Glasgow prognostic score (mGPS) and survival of HCC. However, the results were inconsistent. ⋯ In conclusion, this meta-analysis suggested that mGPS might be an independent prognostic factor for HCC.
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Randomized Controlled Trial
Effects on cognitive function of propofol medium and long chain lipid emulsion in patients with hepatic encephalopathy.
Our study aimed to investigate the effects of propofol medium and long chain lipid emulsion on cognitive function of the patients with hepatic encephalopathy undergoing hemofiltration treatment. ⋯ Based on our results we found that propofol medium-long chain lipid emulsion can significantly improve the curative effect of hemofiltration on patients with hepatic encephalopathy, and can also improve their cognitive function. We recommend the use of this propofol emulsion when considering hemofiltration treatment in this group of patients.
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Review Meta Analysis
Angiotensin receptor blockers and breast cancer risk: a meta-analysis.
Some studies reported that angiotensin receptor blockers (ARBs) reduced the risk of breast cancer. However, other studies did not show similar results. ⋯ This study provided evidence that ARBs was associated with decreased breast cancer in Asians and increased risk of breast cancer in Caucasians.