Sheng li ke xue jin zhan [Progress in physiology]
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Sheng Li Ke Xue Jin Zhan · Oct 2004
Review[Inhibitory proteins against axon regeneration in the central nervous system].
Growth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.
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Sheng Li Ke Xue Jin Zhan · Jul 2004
Review[Progress in the basic research on neurobiological mechanisms of cancer pain].
Pain shows the most disruptive influence on the quality of the life of cancer patients. However, the basic neurobiology of cancer pain is poorly understood, as no appropriate animal model of cancer pain is available. ⋯ Cancer pain has its unique mechanisms such as osteolysis, peripheral sensitization, central sensitization and nerve entrapping, which are all involved in the development and maintenance of cancer pain. Here we summarized the study progress of cancer pain animal models, neurochemical mechanisms and drugs for treatment of cancer pain from recent literatures.