Sheng li ke xue jin zhan [Progress in physiology]
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Sheng Li Ke Xue Jin Zhan · Jan 2004
Review[Current progress of matrix metalloproteinase in acute lung injury following cardiopulmonary bypass].
Degradation of basement membrane of pulmonary capillaries was the main pathological feature of lung injury following cardiopulmonary bypass (CPB). Matrix metalloproteinases (MMPs) contributed to the development of lung injury following CPB via degrading extracellular matrix and regulating cytokines. So, understanding the effects of MMPs in the lung injury following CPB may be helpful to prevent and treat the complications mentioned above.
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Over the last decade, considerable progress has been made in the study of sphingolipids with the development of biological techniques. Sphingolipids play important roles in diverse physiological process, including cytoskeleton migration, angiogenesis, embryonic development and signal transduction. Except for this, the lastest evidence has suggested that sphingolipids and their metabolite (ceramide, sphingosine, sphingosine 1-phosphate) can induce apoptosis in a wide variety of tumor cell lines such as LoVo HT29, Bel7402, A549, CNE2 cells. This paper is attempted to review the recent advances of investigation into the relationship between sphingolipids and apoptosis.
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Sheng Li Ke Xue Jin Zhan · Jul 2003
Review[Current status in drug addiction and addiction memory research].
The central feature of drug addiction is compulsive drug use--loss of control over apparently voluntary acts of drug seeking and drug taking. Drug addiction, as a chronic brain disease, may result from abnormal engagement of long-term associative memory. Addiction and memory are likely to share much in common in the aspects of neural adaptations, synaptic plasticity, and related molecular mechanisms. ⋯ Addiction is closely related to the disorder of associate learning that depends on dopamine. Hippocampus may play a key role in addiction. At last, we put forward the future directions for research.