Acta anaesthesiologica Sinica
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Acta Anaesthesiol. Sin. · Jun 1998
Clinical TrialLong-term continuous infusion of propofol as a means of sedation for patients in intensive care unit: relationship between dosage and serum concentration.
We studied the effect of long-term continuous propofol infusion in patients who were utilizing mechanical ventilation in intensive care unit. The purpose of our study was to identify the appropriate dosage of propofol and to monitor the relating serum level that would provide satisfactory sedative and hypnotic effects to the patients, i.e., to procure a Ramsay Sedation Scale (RSS) value between 2 and 3. ⋯ We concluded that propofol infusion given at a rate of 0.71 +/- 0.31 mg/kg/h and a plasma concentration level of less than 1 microgram/ml would be sufficient to produce a sedation with RSS value between 2 and 3.
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Acta Anaesthesiol. Sin. · Jun 1998
Case ReportsEpidural anesthesia combined with propofol sedation for abdominal hysterectomy in a patient with amyotrophic lateral sclerosis--a case report.
Amyotrophic lateral sclerosis (ALS) is a disease characterized by progressive degeneration of the lower motor neurons, motor nuclei of the brain stem, and the descending pathway of the upper motor neurons. As the disease progresses, atrophy and weakness involve most of the skeletal muscles, including those of the tongue, pharynx larynx and chest. Impairment of respiration, altered response to muscle relaxants, and predisposition of aspiration affect a safe anesthetic management. ⋯ In this report, we described the use of epidural analgesia with 2% lidocaine combined with continuous infusion of low dose propofol for sedation for a ALS patient undergoing abdominal hysterectomy. The anesthetic management of this patient was smooth and successful. Besides, epidural morphine could provide excellent postoperative pain relief without respiratory complications.