Acta anaesthesiologica Sinica
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Acta Anaesthesiol. Sin. · Jun 1998
Clinical TrialLong-term continuous infusion of propofol as a means of sedation for patients in intensive care unit: relationship between dosage and serum concentration.
We studied the effect of long-term continuous propofol infusion in patients who were utilizing mechanical ventilation in intensive care unit. The purpose of our study was to identify the appropriate dosage of propofol and to monitor the relating serum level that would provide satisfactory sedative and hypnotic effects to the patients, i.e., to procure a Ramsay Sedation Scale (RSS) value between 2 and 3. ⋯ We concluded that propofol infusion given at a rate of 0.71 +/- 0.31 mg/kg/h and a plasma concentration level of less than 1 microgram/ml would be sufficient to produce a sedation with RSS value between 2 and 3.
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Acta Anaesthesiol. Sin. · Jun 1998
Case ReportsEpidural anesthesia combined with propofol sedation for abdominal hysterectomy in a patient with amyotrophic lateral sclerosis--a case report.
Amyotrophic lateral sclerosis (ALS) is a disease characterized by progressive degeneration of the lower motor neurons, motor nuclei of the brain stem, and the descending pathway of the upper motor neurons. As the disease progresses, atrophy and weakness involve most of the skeletal muscles, including those of the tongue, pharynx larynx and chest. Impairment of respiration, altered response to muscle relaxants, and predisposition of aspiration affect a safe anesthetic management. ⋯ In this report, we described the use of epidural analgesia with 2% lidocaine combined with continuous infusion of low dose propofol for sedation for a ALS patient undergoing abdominal hysterectomy. The anesthetic management of this patient was smooth and successful. Besides, epidural morphine could provide excellent postoperative pain relief without respiratory complications.
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Acta Anaesthesiol. Sin. · Mar 1998
Randomized Controlled Trial Clinical TrialEffect of BL-10 (tianzhu), BL-11 (dazhu) and GB-34 (yanglinquan) acuplaster for prevention of vomiting after strabismus surgery in children.
Stimulation of P6 (Neiguan) acupoint can prevent nausea and vomiting in adults. However, there is no antiemetic effect in children undergoing strabismus surgery. The effect of P6 may act only on hollow organs; in contrast, BL-10 (Tianzhu), BL-11 (Dazhu) and GB-34 (Yanglinquan) are more related to the meridians of the eye. Therefore these three more relevant acupoints, BL-10, BL-11 and GB-34 were stimulated to evaluate the antiemetic effect in children undergoing strabismus surgery. ⋯ The results demonstrated that prophylactic use of bilateral noninvasive acuplaster on the BL-10, BL-11, and GB-34 acupoints significantly reduces vomiting after strabismus correction. The mechanism may be dispersal of these three acupoints, thus diminishing the parasympathetic stimulation resulting from surgical traction of eye muscles.
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Acta Anaesthesiol. Sin. · Mar 1998
Randomized Controlled Trial Comparative Study Clinical TrialComparison of local infiltration of tenoxicam and intravenous tenoxicam for postoperative analgesia in herniorrhaphy.
The major complaint of herniorrhaphy is postoperative pain which occurs during the first 24 h after operation. Tenoxicam has a long half-life of 60-80 h. Local infiltration of the drug concentrates the pain control effects in the local area. The local infiltration dose can be smaller than the recommended systemic dose needfully to reach the target area to be effective. Therefore we studied the effect of preoperative local infiltration of tenoxicam on postoperative pain. ⋯ Preoperative local infiltration of tenoxicam can decrease postoperative pain score significantly during the most painful period (24 h) in herniorrhaphy.