The Journal of dermatologic surgery and oncology
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J Dermatol Surg Oncol · Oct 1993
Topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. A dermatologic experience.
Topical silicone gel sheeting has been used successfully in the management of hypertrophic and keloid scars resulting from thermal burn wounds. ⋯ Topical silicone gel sheeting is an effective method for the treatment of hypertrophic and keloid scars and may be considered useful in the treatment of these difficult cutaneous lesions.
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J Dermatol Surg Oncol · Mar 1993
Comparative Study Clinical Trial Controlled Clinical TrialLess painful alternatives for local anesthesia.
Infiltration of commonly used local anesthetics is painful. It has been speculated that the pain on infiltration is a direct consequence of the acidity of the anesthetic solution. ⋯ The pH values of bacteriostatic saline solution with epinephrine 1:300,000 and lidocaine with epinephrine diluted with bacteriostatic saline solution are 5.3 and 4.2, respectively. Both were found to be less painful than 1% lidocaine with epinephrine with sodium bicarbonate 84 meq/mL, which had a pH of 7.4. It is unlikely that the pain of infiltration is a simple function of the pH of the anesthetic solution.
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Hypertrophic scarring and keloid formation are clinical problems with effectively limited solutions. Although numerous methods have been devised to combat them, this article focuses on promising pharmacologic strategies that target collagen metabolism. ⋯ Furthermore, interference of extracellular matrix-enhancing cytokines, such as TGF-beta, may be an effective solution to keloids and hypertrophic scars. Additional research of soluble cytokine receptors, autoantibodies to cytokines, cytokine receptor antagonists, and cytokine-binding molecules may lead to the development of better therapeutic agents.
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J Dermatol Surg Oncol · Nov 1992
Comparative StudyThe postoperative use of wound adhesives. Gum mastic versus benzoin, USP.
Our results, combined with the work of previous authors, show that gum mastic not only offers superior adhesive qualities compared with benzoin, USP but also has a lower incidence of postoperative contact dermatitis and subsequent skin discoloration. In light of the widespread use of surgical adhesives, this study is important in documenting the low incidence of complications and the advantages of gum mastic compared with benzoin, USP.