Clinical orthopaedics and related research
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Clin. Orthop. Relat. Res. · Mar 2003
Long-term administration of clodronate does not prevent fracture healing in rats.
Clinicians have been concerned that fractures do not heal properly in individuals exposed to bisphosphonate treatment, a treatment that strongly affects bone metabolism. The current study attempted to clarify the long-term effects of clodronate (dichloromethylene bisphosphonate) treatment on fracture healing in growing rats. Clodronate was administered subcutaneously twice a week in a dose of 2 mg/kg or 10 mg/kg. ⋯ Clodronate treatment does not seem to prolong the fracture healing process, even when administered on a long-term basis before the fracture. Clodronate increases the size of the callus, but has only a minor effect on its biomechanical properties. The current results suggest that long-term clodronate treatment does not inhibit fracture healing.
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Clin. Orthop. Relat. Res. · Mar 2003
Gun control in the United States: ethical perspectives for the twenty-first century.
The current author will explore the way we should think about the ethical implications of gun control in the United States today. The generating pedagogy will be: (1) an explication of worldview perspectives, personal and community as per the author's recently published writings; (2) a discussion of the worldviews of both sides of the gun control debate; (3) a critical appraisal of the positions of each side; and (4) some suggestions about a future that is without ordinary citizen ownership of guns. The author argues that based on an ethical rights model of analysis, an ordinary citizen's right to bear arms is outweighed by other competing rights claims.