Clinical orthopaedics and related research
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Clin. Orthop. Relat. Res. · Oct 2018
High Risk of Venous Thromboembolism After Surgery for Long Bone Metastases: A Retrospective Study of 682 Patients.
Previous studies have shown that venous thromboembolism (VTE) is a complication associated with neoplastic disease and major orthopaedic surgery. However, many potential risk factors remain undefined. ⋯ Level III, therapeutic study.
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Clin. Orthop. Relat. Res. · Oct 2018
Comparative StudyExternal Beam Irradiation Preferentially Inhibits the Endochondral Pathway of Fracture Healing: A Rat Model.
External beam irradiation is an accepted treatment for skeletal malignancies. Radiation acts on both cancerous and normal cells and, depending on the balance of these effects, may promote or impair bone healing after pathologic fracture. Previous studies suggest an adverse effect of radiation on endochondral ossification, but the existence of differential effects of radiation on the two distinct bone healing pathways is unknown. ⋯ This work suggests that there may be a rationale for compression plating rather than intramedullary nailing of long bone fractures in select circumstances where bony union is desirable, adjunctive radiation treatment is required, and bone stock is sufficient for plate and screw fixation.