Journal of neurology
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Journal of neurology · Jan 2008
Clinical TrialHigh field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria.
To prospectively investigate metabolic changes in the normal-appearing white matter (NAWM) of patients presenting with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) and to correlate these changes to conventional MR imaging findings in terms of MR imaging criteria. ⋯ As assessed by (1)H-MRS a significant axonal damage already occurs during the first demyelinating episode in patients with CIS. Conventional MR imaging in terms of diagnostic imaging criteria does not significantly reflect NAWM disease activity in terms of metabolic alterations detected by (1)H-MR spectroscopy.
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Journal of neurology · Oct 2007
Sporadic adult onset ataxia of unknown etiology : a clinical, electrophysiological and imaging study.
The sporadic adult onset ataxias of unknown etiology (SAOA) denote the non-hereditary degenerative adult onset ataxias that are distinct from multiple system atrophy (MSA). ⋯ The data show that SAOA is a predominantly, but not exclusively cerebellar disorder. Clinical, electrophysiological, and imaging findings showed some similarities with multiple system atrophy which raises the question of an overlap of these two disorders.
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Journal of neurology · Oct 2007
Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unit.
To determine independent clinical predictors of stroke-associated pneumonia (SAP) that are available in all patients on day of hospital admission. ⋯ Increased risk of pneumonia in acute stroke patients can be sufficiently predicted by a small set of clinical risk factors.
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Journal of neurology · Sep 2007
Apathy and verbal fluency in STN-stimulated PD patients. An observational follow-up study.
To evaluate apathy and its relation to verbal fluency tasks in a consecutive series of 19 patients with Parkinson's disease (PD) submitted to deep brain stimulation of the subthalamic nucleus (DBS of STN). ⋯ The results of the present study suggest that DBS of STN does not necessarily induce apathy even if individual patients show a moderate post-operative worsening of apathetic symptoms.