Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
-
Sichuan Da Xue Xue Bao Yi Xue Ban · Jul 2013
[Influence of 20% lipid emulsion on drug concentration, distribution volume and pharmacology effect of continuous infusion of propofol in rabbits].
To investigate the influence of 20% lipid emulsion on drug plasma concentration, distribution volume and pharmacology effect of propofol administered with constant rate intravenous infusion in rabbits. ⋯ Amelioration of pharmacology effect of propofol with high rate lipid infusion is associated with reduced V, Vss, elevated propofol plasma concentration and lowered propofol brain tissue concentration. 20% lipid will not influence these indice when infused with low rate, indicating that lipid in TPN will not change the sedation effects of propofol.