Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
-
Sichuan Da Xue Xue Bao Yi Xue Ban · Nov 2014
[Inhibition of HCN1 channels by ketamine accounts for its antidepressant actions].
To investigate the roles of hyperolarization-actived cyclic nucleotide-gated channels 1 (HCN1) in antidepressant actions of ketamine (KET). ⋯ Inhibition of HCN1 channels by ketamine accounts for its antidepressant actions.
-
Sichuan Da Xue Xue Bao Yi Xue Ban · Nov 2014
[Regulation of Thl/Th2 cells by T cell-mediated transcription factor in rats with chronic obstructive pulmonary disease].
To determine T box expressed in T cells (T bet), GATA binding protein-3 (GATA 3), and retinoid-related orphan nuclear receptor gammat (RORgammat) in rats with chronic obstructive pulmonary disease (COPD). ⋯ Imbalanced regulation of T bet / GATA 3 and RORgammat on Th1/Th2 and Th17 cells is associated with the occurrence of COPD.
-
Sichuan Da Xue Xue Bao Yi Xue Ban · Jul 2014
Randomized Controlled Trial[A clinical trial of ultrasound-guided facet joint block in the lumbar spine to treat facet joint related low back pain].
To determine the feasibility and clinical efficacy of ultrasound-guided facet joint injection and nerve block in lumbar facet joint for the treatment of facet-joint related low back pain. ⋯ The ultrasound-guided lumbar facet joint injection technique had a high feasibility and accuracy, and had better clinical efficacy than block blindly.
-
Sichuan Da Xue Xue Bao Yi Xue Ban · Jul 2014
[Advances in the target therapy of hematological malignancies].
With the rapid development of modern bio-medical technology, the pathogenesis of hematological malignancies including leukemia, lymphoma, myeloma has been illustrated with more and more attractive details. The diagnosis of hematological malignancies now becomes more precisely and clarified based on the progress than ever before, and the treatments of hematological malignancies keep the evolution in the way of integrating the novel molecular target drugs with conventional chemotherapy, radiotherapy, hematopoietic stem cell transplantation. The pivotal progress in the target therapy of hematological malignancies includes tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia, CD20 monoclonal antibody treatment of B-cell lymphoma and CD20 positive leukemia, FLT3 inhibitors fo the treatment of FLT3 mutation positive high-risk acute myelogenous leukemia. The topics of this issue focus on the advances in this field, which reflects the new achievements in the research of hematological malignancies, and the trends of precise and stratified diagnosis as well as tailored target therapy in the future.
-
Sichuan Da Xue Xue Bao Yi Xue Ban · May 2014
[Clinical features, quality of life and psychological health of patients with irritable bowel syndrome and functional dyspepsia].
To investigate severity of gastrointestinal symptoms, quality of life, and mental health status of patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). ⋯ IBS-FD patients especially those with constipation suffer more gastrointestinal discomforts, and are more likely to suffer from anxiety and depression and poor quality of life compared with those with IBS only.