Fortschritte der Medizin
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Fortschritte der Medizin · Nov 1991
Randomized Controlled Trial Clinical Trial[Therapy of orthostatic disorders of cardiovascular regulation. Placebo controlled double-blind study with oxilofrine].
In a double-blind study, the antihypotensive agent oxilofrine was compared with placebo in patients suffering from orthostatic circulatory regulation disorders of the sympathicotonic type. After a washout period of one week, 30 patients were treated for two weeks with oxilofrine and 30 with placebo. ⋯ The difference in the primary variable was significant. The systolic pressure at the end of treatment with oxilofrine in the Schellong test was virtually constant; under placebo, the systolic pressure decreased.
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The most important studies on weather-related pain have been analysed and their results compared. Since different medicometeorological classifications were used, and individual reactions to the weather vary considerably, it is possible to recognize unequivocal, universally valid relationships only with difficulty. ⋯ Headaches and migraine are typical signs of an imminent change in the weather. The question as to whether or not the endorphin concentration is of significance for meteorogenic pain is discussed, and possible influences of atmospherics activity noted.