Fortschritte der Medizin
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Fortschritte der Medizin · Sep 1993
Case Reports[Oral combination therapy of zoster neuralgia. Pain reduction by 1-adamantanamine sulfate and carbamazepine per os].
In four patients hospitalized with severe neuralgic complaints in conjunction with a Zoster infection, the pain-relieving effect of oral 1-adamantanamine sulfate used in combination with carbamazepine was studied. From the results obtained, the oral administration of 1-adamantanamine sulfate also appears to have a reliable analgesic effect, so that ambulatory treatment is readily possible.
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Fortschritte der Medizin · Aug 1993
Review[Indications spectrum for beta-1-selective adrenergic receptor blockers].
The major indications for beta receptor blockers include, in addition to arterial hypertension, various clinical manifestations of coronary heart disease. Used as antihypertensive agents, beta receptor blockers bring about regression of myocardial hypertrophy and an improvement in diastolic ventricular function. ⋯ A detailed knowledge of the subtypes of adrenoceptors--in particular beta-1 receptors in the case of the heart--led to the development of largely organ-specific antagonists. In contrast to nonspecific beta blockers, beta-1 selective substances, for example, atenolol, have only a mild, clinically non-relevant, effect on glucose and lipid metabolism.