Voprosy virusologii
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Voprosy virusologii · Mar 1994
Comparative Study[The results of a study of the data obtained from patients vaccinated earlier with different influenza vaccines].
Studies of influenza virus type A and B strains isolated during the epidemics of 1990 and 1991 in Novgorod from sick children previously vaccinated with influenza vaccines demonstrated no influence of postvaccination immunity on the antigenic properties of the isolates from patients with different vaccination history. Under conditions of the concurrent circulation of viruses with previously known and new antigenic structures the difference in the immune response consisted in its greater stimulation of this response to new influenza virus strains.
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Voprosy virusologii · Nov 1990
[The role of Hantaan virus serotypes in the etiology of hemorrhagic fever with renal syndrome in the Far East of the USSR].
The employment of two serological tests (indirect fluorescence antibody technique and neutralization test) demonstrated the leading role of Hantaan virus serotype 1 strains isolated from field mice in the pattern of the incidence of hemorrhagic fever with renal syndrome (HFRS). Proofs of the etiological importance of strains of serotypes 3 and 5 occurring in brown rats and Cl. rufocanus were obtained. No data on any association of human HFRS cases with strains of serotype 4 isolated from reed voles could be demonstrated.
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Voprosy virusologii · Sep 1990
Comparative Study[Hantaan virus serotypes circulating in foci of the Far Eastern region of the USSR].
Studies on serodifferentiation by indirect immunofluorescence antibody method and neutralization test of Hantaan virus strains isolated from human patients and rodents revealed circulation on the Maritime Territory of 5 virus serotypes and demonstrated that rodents of one species could be virus carriers of different virus serotypes. On the basis of the antigenic similarity of strains isolated from human patients, field mice, and Clethrionomys rufocanus it is concluded that the virus serotypes circulating among rodents of these species may play a role in the etiology of cases of hemorrhagic fever with renal syndrome.
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Voprosy virusologii · Mar 1986
[Indirect immunoenzyme method for the laboratory diagnosis of Lassa and Ebola hemorrhagic fevers].
Conditions for performing solid-phase indirect enzyme-immunoassay (SPEIA) for the detection of Lassa and Ebola virus antigens and antibodies to them using horseradish peroxidase-labeled antispecific globulins were developed. The method is highly sensitive, specific, and reproducible. By this method, antigens of Lassa and Ebola viruses could be detected in tissue culture fluid of the infected cell cultures and in animal organ suspensions. Detection of antibodies to Lassa and Ebola viruses in human convalescent sera and in normal donors by means of SPEIA opens possibilities for its use in large-scale diagnostic and seroepidemiological surveys.