Scandinavian journal of gastroenterology. Supplement
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Scand. J. Gastroenterol. Suppl. · Jan 1984
The ulcer risk in reflux preventive gastric operations. An experimental study.
The ulcer risk of duodenogastric antireflux operations following gastric resection was analyzed experimentally in 162 rats. After gastric resection a Roux-Y gastrojejunostomy or jejunal transposition of various length were done. 10 month postoperatively a follow-up was performed consisting of endoscopy, analysis of gastrin and gastric secretion, gastric emptying tests and histamine stimulation. A high incidence of stomal ulceration was found, which was directly related to the length of the interposed jejunal segment. ⋯ The aetiology of these ulcers seems to be acid related, because all reflux-free stomachs showed a very low pH. Reflux preventive operations are demonstrated to be a modification of the Mann-Williamson experiment. They should be used carefully or avoided.
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Scand. J. Gastroenterol. Suppl. · Jan 1984
ReviewFactors that might influence the outcome of studies on the aetiology and epidemiology of acute pelvic inflammatory disease.
An overview is presented of the various factors that might influence the outcome of aetiological and epidemiological studies of pelvic infections in women. Some diversities of opinion in these respects might be explained by i.a. inprecise definitions, lack of simple and specific diagnostic methods, differences in patient selection and laboratory techniques.
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In 62 patients the late results of isoperistaltic jejunal interposition in reconstructive ulcer surgery are analyzed 1.5 to 9.5 years postoperatively (mean 3.1 years); a follow up was possible in 58 patients. 38 (65.5%) had a Visick I or II result; 16 (28%) a fair result (Visick III) and 4 a poor result (Visick IV). 12 of the 58 followed up patients developed a jejunal stomal ulceration in the mean time. These ulcerations were mostly (60%) asymptomatic, superficial and nonbleeding. The histology of the gastric remnant remained unchanged in the most patients and didn't show any benefit of bile diverting operation. ⋯ Similar reports are found in the literature. Even an additional vagotomy doesn't prevent the ulcer formation sufficiently in every case. In conclusion reflux-preventive jejunal interposition is shown to be heavily ulcer-prone, it should be used in reconstructive ulcer surgery very carefully only with short (15 cm) segments and additional vagotomy.
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Scand. J. Gastroenterol. Suppl. · Jan 1984
The role of bile salts in cysteamine-induced duodenal ulcer in the rat and the ulceroprotective property of lysolecithin.
Cysteamine induces duodenal ulcers in rats, but bile diversion inhibits ulcer formation. Since lysolecithin inhibits stress ulceration in rats, it is assessed now whether lysolecithin inhibits cysteamine-induced ulcers, too. Male rats were operated: division of the duodenum distally to the pylorus, duodenojejunostomy. Roux-en-Y duodenojejunostomy. 4 groups comprising 10 animals. Drinking solution for group 1, 3 and 4: Na taurocholate and glycocholic acid (5 mmol/l). For group 2 addition of 0.2 mmol/l lysolecithin. Cysteamine-HCl (10%) twice subcutaneously on the 19th day in group 1, 3 and 4, isotonic NaCl in group 2. In group four 1 ml lysolecithin per gastric tube 1 h before cysteamine. ⋯ Lysolecithin, a substance produced during fat digestion, exerted an ulceroprotective property (lyso-protection) under experimental conditions, as shown here for the first time, to the author's knowledge. The enhancement of cysteamine-induced duodenal ulcer development by bile salts is again documented.