Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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To investigate the effects of hyperglycemia on persistent Na+ currents in human diabetic nerves, eliminating the factors of passive membrane properties as a factor. Previous studies show that strength-duration time constant of a nerve is shortened under hyperglycemia, suggesting reduced axonal persistent Na+ currents. However, the time constant is also affected by changes in passive membrane properties. Latent addition using computerized threshold tracking is a new method that can separately evaluate Na+ currents and passive membrane properties. ⋯ Reduced nodal Na+ currents may partly contribute to the pathophysiology of human diabetic neuropathy.
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To investigate the effect of psychological arousal on pain ratings and the R2 component of the electrically evoked blink reflex to a 'pure' noiciceptive stimulus. ⋯ Supra-spinal influences need to be considered during clinical evaluation of the trigeminal nociceptive blink reflex.