Evidence-based dentistry
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Evidence-based dentistry · Jan 2006
CommentSeveral therapies may prevent or reduce the severity of oral mucositis associated with cancer treatment.
The Cochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials, Medline and Embase were searched to April 2006. Reference lists from relevant articles were scanned and the authors of eligible studies were contacted to identify trials and obtain additional information. ⋯ Several of the interventions were found to have some benefit at preventing or reducing the severity of mucositis associated with cancer treatment. The strength of the evidence was variable and implications for practice include consideration that benefits may be specific for certain cancer types and treatment. There is a need for well-designed RCT with sufficient numbers of participants to perform subgroup analyses by type of disease and chemotherapeutic agent.
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To investigate the incidence and time taken to full publication of abstracts presented at dental scientific meetings. ⋯ More than half of the research presented at EOS, IADR and ORCA in 1993 remained unpublished 5 years after presentation at the conference. Oral presentations were published more frequently than poster presentations.
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Evidence-based dentistry · Jan 2005
CommentGood evidence for effectiveness of analgesics most commonly prescribed by UK dentists. What is the relative efficacy of single-dose oral analgesics after third molar extraction?
Dental trials were sought among systematic reviews of randomised, double-blind studies of analgesics in acute pain, which were identified from the Cochrane Library, Biological Abstracts, MEDLINE, PubMed and the Oxford Pain Relief database. ⋯ NSAID and COX-2 inhibitors have the lowest (best) NNT. These may also have fewer adverse effects after third molar surgery, but conclusive evidence is lacking. At least 80% of analgesic prescribing by UK dentists is in line with the best available evidence on efficacy and safety.