Acta pathologica japonica
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Acta pathologica japonica · Jun 1988
Comparative StudySchmorl's nodes. Correlation of X-ray and histological findings in postmortem specimens.
Histological examinations were conducted on specimens of 368 intervertebral discs (T11/12-L5/S1), using X-ray photography and discography. Specimens were obtained from 61 individuals (36 males and 25 females) whose ages ranged from 25 to 85 years. Fifty-four Schmorl's nodes were found in 28 of the patients (19 males and 9 females), and in 43 discs. ⋯ Among these discs, 10 showed a limited form of shadow and 25 showed a diffuse form, and Schmorl's nodes were detected in 11 that showed a diffuse form of shadow. It was possible to detect Schmorl's nodes when they were contiguous with a degenerated annulus fibrosus adjoining the nuclear cavity. Pathogenetically, the presence of Schmorl's nodes in patients of middle and advanced age is interpreted to be one of the symptoms of age-related changes in the cartilaginous plate.
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Acta pathologica japonica · Nov 1985
Case ReportsCreutzfeldt-Jakob disease. An autopsy case of the panencephalopathic type and a review of the literature.
This is a case report of a purported panencephalopathic type of Creutzfeldt-Jakob (C-J) disease in a 61-year-old Japanese farmer. He died nine months after the onset of clinical symptoms. This variety of C-J disease was named and reported in 1981 by Mizutani. ⋯ The case was diagnosed clinically and at post mortem marked neural loss, astrocytic macrogliosis, and degeneration of subcortical white matter were found. Senile plaques and neurofibrillary tangles were virtually absent. Degeneration of the white matter is uncommon in C-J disease, and when it occurs is usually mild, and limited in distribution.
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Acta pathologica japonica · Nov 1982
Case ReportsMixed connective tissue disease with fatal pulmonary hypertension.
An autopsy case of mixed connective tissue disease (MCTD) with pulmonary hypertension is presented. A 34-year-old woman suffering from arthralgia, Raynaud's phenomenon, and dyspnea of 6-years duration was diagnosed as having MCTD on the basis of a high titer (1:160,000) of serum antibody to the ribonuclease-sensitive component of extractable nuclear antigen. Examination of cardiac function revealed the complication of pulmonary hypertension. ⋯ Typical plexiform lesions of these vessels were also observed. These findings coincide with those of plexogenic pulmonary angiopathy of primary pulmonary hypertension (PPH). This is the second autopsy case of MCTD with fatal pulmonary hypertension reported and our observations suggest that some cases with PPH who had immunological abnormalities but could not be classified as cases of classical collagen disease, may have been induced by MCTD.
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Acta pathologica japonica · Jan 1982
Historical ArticleA seventy-year history of the Japanese pathological society.
This paper provides the chronological outline of the Society's activities during the past seventy years. Membership, which started from a mere 204, has now reached a total of nearly 3,000. This seventy-year history shows that the Society has repeatedly adapted itself to the progress of science and to the trends of the time.
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Acta pathologica japonica · Sep 1978
Case ReportsEctopic ACTH-MSH producing carcinoid tumor with multiple endocrine hyperplasia in a child.
An autopsy case of a 9-year-old Japanese girl revealed a carcinoid tumor originating in the duodenum and hyperplasia of the multiple endocrine organs as manifested by ectopic ACTH syndrome, carcinoid syndrome and giantism. The tumor cells were positive for histochemical argyrophile reaction and two types of secretory granules were identified by electron microscopy. ⋯ This case was considered to be a type of multiple endocrine adenomatosis including carcinoid tumor. The relationship between the carcinoid tumor and multiple endocrine adenomatosis was discussed.