Nigerian quarterly journal of hospital medicine
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The growing popularity of day-case surgery derives mainly from its twin benefits of convenience and cost-effectiveness. It is particularly useful in treating inguinal hernia which remains one of the most common presenting surgical problems. ⋯ The study showed that post-operative pain is the commonest complication of day-case inguinal hemiotomy and herniorrhaphy. Wound infection was however the most common significant complication. The overall outcome was good.
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Proper and adequate pharmacovigilance is lacking in children's drug therapy, especially in developing countries. Therefore these children are at risk of developing adverse reactions to drugs as a result of medication errors. Having a better understanding of the types of error in a teaching hospital would be an important step toward quality improvement in children drug therapy. ⋯ Children presenting to the LASUTH are at a greater risk of adverse drug reactions from overdosage prescriptions and are also facing the risk of treatment inadequacy and failure from underdosage prescriptions. Therefore a monitoring committee is urgently required to be put in place to review all paediatric prescriptions for appropriateness, adequacy and dosage accuracy using the patient's weight, age, and other appropriate indicator(s) before dispensing and/or refill for paediatric patients. Also rational drug prescription should form part of the monthly continuous medical education of the hospital with much focus on the paediatric doctors.
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Comparative Study Controlled Clinical Trial
Comparison of the effects of tens and sodium salicylate iontophoresis in the management of osteoarthritis of the knee.
The aim of this study was to compare the effects of transcutaneous electrical nerve stimulation (TENS) and sodium salicylate Iontophoresis on pain and functional disability in patients with osteoarthritis of the knee. Twenty (20) subjects participated in this study. Their ages ranged from 40-65 years. ⋯ The statistical analysis of the result showed a statistically significant reduction in pain and functional disability in both groups (P < 0.05). Patients treated with Sodium salicylate iontophoresis had a more statistically significant reduction of pain and functional disability in comparison with TENS group (P < 0.05). It is hereby suggested that the use of sodium salicylate iontophoresis and TENS be included in treatment of osteoarthritis to enhance pain relief and functional activity.
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The analgesic, antipyretic and anti-inflammatory effects of the aqueous extract of Mezoneuron benthamianum (MB) were evaluated in mice, rats and rabbits using the mouse writhing, tail flick, hot plate and formalin-induced pain tests; 2-4-Dinitrophenol (DNP), D-Amphetamine and E-coli Lipopolysaccharide-induced pyrexia and carrageenan, egg albumin and xylene-induced oedema. The extract (400-1600 mg/kg) and acetylsalicylic acid (100 mg/ kg) produced a significant (P < 0.05) inhibition of the second phase response in the formalin pain model, while only the highest dose (1600 mg/kg) of the extract showed a comparable antinociceptive effect in the first phase. The extract also showed a dose-dependent inhibition of acetic acid induced abdominal writhing. ⋯ Administration of the extract up to 2 g/kg (orally) did not produce any toxic effect in the acute toxicity studies in mice. The LD50 of the extract when administered intraperitoneally was 1021.31 mg/kg. The data obtained show that MB extract possesses analgesic and antipyretic activities but lacks an anti-inflammatory property.