Deutsche medizinische Wochenschrift
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Dtsch. Med. Wochenschr. · Apr 2022
Letter[Considerations on Excess Mortality in Germany in the year 2020 and 2021].
At the end of 2020, in Germany a discussion broke out whether the past year was characterized by excess mortality. The opposite positions arose primarily from the way data was processed. In order to correct systematic trends of the last two decades, in the present study the annual death rates for Germany were calculated as the difference to those of the year 2000 and a polynomial fit of 2nd order was carried out for the total population and for the groups of people below and from 80 years of age. ⋯ For the total population there were excess mortality rates for 2020 and 2021 with 11 500 and 10 468 deaths respectively, which in which in total is completely covered by the excess mortality of those aged 80 and over. In the age group below 80 years there was no excess mortality in the two years. For all age groups, excess mortality was most prominent in the year 2003.
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Arterial hypertension affects about one third of the German population with a prevalence increasing with age up to 60 %. Globally, more than a quarter gedoppelt of the population are considered hypertensive, resulting in a total of more than one billion people. ⋯ Less than every second patient knows about his or her disease status and less than 40 % of patients in Europe show adequate blood pressure control with a treatment target of < 140/90 mmHg despite antihypertensive treatment. This overview of arterial hypertension, its etiology, diagnostic tools, and therapeutic options aims to improve the understanding of arterial hypertension and to facilitate the diagnostic and therapeutic approach, eventually resulting in a better and more successful handling of patients with arterial hypertension.
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Cardiac nuclear medicine comprises various diagnostic techniques using radiopharmaceuticals for functional imaging in vivo. This article provides an overview of current clinical use of cardiac imaging in nuclear medicine in Germany: Myocardial perfusion imaging using SPECT is a well-established noninvasive tool to semi-quantitatively measure left ventricular myocardial perfusion. Ischemia and chronic myocardial scars can be idenified with a high diagnostic accuracy. ⋯ A potenitally harmful myocardial biopsy often is not needed any more and specific therapy can be initiated. In summary, diagnostic methods in cardiac nuclear medicine non-invasively allow visualization and function analysis of biological processes and are essential for diagnosis finding and therapy guidance. The continuous advancement of diagnostic tools makes nuclear cardiology a highly relevant and interesting field.
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Dtsch. Med. Wochenschr. · Apr 2022
Review[Genetic diseases of lipid metabolism - Focus familial hypercholesterolemia].
Congenital disorders of lipid metabolism are characterised by LDL-C concentrations > 190 mg/dl (4.9 mM) and/or triglycerides > 200 mg/dl (2.3 mM) in young individuals after having excluded a secondary hyperlipoproteinemia. Further characteristics of this primary hyperlipoproteinemia are elevated lipid values or premature myocardial infarctions within families or xantelasms, arcus lipoides, xanthomas and abdominal pain. This overview summarises our current knowledge of etiology and pathogenesis of primary hyperlipoproteinemia.