Deutsche medizinische Wochenschrift
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Amyloidosis are rare protein misfolding and deposition diseases which, with very few exceptions, are treatable easily nowadays. The prognosis depends on the form of amyloidosis, which is particularly unfavorable for heart involvement that is diagnosed too late. ⋯ Once the diagnosis has been made, treatment should be started without delay. Amyloidosis centers offer support in the diagnosis and development as well as clinical trials of an optimal therapy concept.
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Dtsch. Med. Wochenschr. · Oct 2024
[The pulmonary nodule: from incidental finding to pathological confirmation].
As the number of CT examinations of the lungs increases, so does the prevalence of incidentally discovered pulmonary nodules. While most lung nodules are benign, the risk of malignancy significantly rises with the presence of risk factors and specific imaging features. ⋯ Additionally, the decision regarding histologic confirmation should consider the patient's comorbidities, preferences, and the examiner's expertise. Emerging sampling technologies provide methods for addressing peripheral lung nodules with minimal risk of complications.
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Food allergies are divided into 2 main categories: IgE-mediated and non-IgE-mediated food allergies. Both forms can have significant health effects but differ in mechanism, symptoms, and management. The manifestation of the 2 forms differs between children and adults. ⋯ This article provides an in-depth review of both types of food allergy, discussing their potential causes, diagnostic possibilities, and available therapeutic strategies. Some diseases represent a mixed form of IgE and non-IgE-mediated immunological adverse reactions. Eosinophilic oesophagitis is the most common eosinophilic disease, and the diagnosis and treatment options are explained in more detail below.
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Dtsch. Med. Wochenschr. · Sep 2024
[Multi-resistant bacteria - epidemiological trends and new treatment options].
Multi-resistant bacteria such as Escherichia coli and Klebsiella pneumoniae are a growing threat worldwide. The spread of Carbapenemase-producing strains is particularly worrying. New antibiotics and combination therapies offer treatment options, but the development of resistant pathogens remains a major challenge.
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Dtsch. Med. Wochenschr. · Sep 2024
Comparative Study[Comparison of LDL cholesterol serum concentrations in patients after acute coronary syndrome between 2018 and 2022 in Germany and Europe].
ESC/EAS guidelines for the management of dyslipidemia after acute coronary syndrome (ACS) were updated in 2019 with lower LDL cholesterol (LDL-C) goals. Their effect on LDL-C lowering in Germany and across Europe is not known. The EuroPath IV survey was designed to compare the lipid management in patients post ACS in the year 2022 with 2018. ⋯ Achievement of LDL-C goals improved after the update of the ESC/EAS lipid guidelines in 2019 but LDL-C goal achievement remains still very low. Even less patients in Germany achieved the LDL-C goals compared to other European countries.