Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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Proc. Soc. Exp. Biol. Med. · Oct 1983
Effect of body temperature on salicylate-induced hyperventilation.
Hyperventilation and hyperpyrexia occur simultaneously during acute salicylate intoxication. The present experiments were designed to investigate the stimulatory effect of increased body temperature on respiration in this pathological state. ⋯ The increase in ventilation of normothermic animals can be explained as a rise in alveolar ventilation which results in hypocapnia despite large increases in carbon dioxide production and oxygen consumption during acute salicylate intoxication. The further augmentation of ventilation in hyperthermic animals can be explained as a rise in deadspace ventilation in response to increased body temperature during acute salicylate intoxication.
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Proc. Soc. Exp. Biol. Med. · Mar 1975
The effect of hyperbaric exposure of 20 atmospheres-absolute (He-O2) on sphingoglycolipids of rat tissues.
The effect of hyperbaric exposure of helium-oxygen at 20 atmospheres-absolute (ATA) on sphingoglycolipids of rat liver, kidney, lung and spleen was studied. No changes were found in the total lipids of the tissues of rats held in ambient air, helium-oxygen mixtures at 1 ATA and 20 ATA. ⋯ Greater changes were observed in the amount of glycolipids from liver and kidney of animals held at 1 ATA and 20 ATA, providing additional evidence that helium can affect cellular metablism at ambient pressure. Chain elongation of fatty acids was observed in glycolipids of liver, kidney and spleen of rats exposed to helium-oxygen at 20 ATA compared to animals held in helium-oxygen at 1 ATA.