Current gastroenterology reports
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Pancreatic endocrine tumors are rare neoplasms accounting for less than 5% of pancreatic malignancies. They are broadly classified into either functioning tumors (insulinomas, gastrinomas, glucagonomas, VIPomas, and somatostatinomas) or nonfunctioning tumors. ⋯ Surgical resection remains the treatment of choice even in the face of metastatic disease. Further development of novel diagnostic and treatment modalities offers potential to greatly improve quality of life and prolong disease-free survival for patients with pancreatic endocrine tumors.
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Curr Gastroenterol Rep · Aug 2008
ReviewNovel techniques to study visceral hypersensitivity in irritable bowel syndrome.
Visceral hypersensitivity has emerged as a key hypothesis in explaining the painful symptoms of irritable bowel syndrome (IBS), and it has been proposed as a "biologic marker" for the condition. Visceral hypersensitivity can be influenced by peripheral and central mechanisms affecting pain perception. The optimal method for its assessment in humans has not been determined. ⋯ Studies using electrical stimulation and the RIII lower limb reflex have further confirmed enhanced visceral perception in IBS. Evidence from more recent neuro-imaging studies suggests that IBS patients have abnormal activation of brain circuits involved in emotional and cognitive modulation of sensory information, resulting in ineffective pain modulation; these circuits may have a pathophysiologic role in enhancing visceral perception. There are few effective pharmacologic treatments that relieve IBS symptoms, and improved understanding of brain-gut interactions and factors relating to enhanced visceral perception may guide us in developing more efficacious treatments.
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Several clinical and methodologic difficulties occur when diagnosing acute pancreatitis in the pediatric age group. Due to its uncommonness and heterogeneous symptoms, acute pancreatitis in children is often misdiagnosed, and prospective studies are lacking. Guidelines for classifying, diagnosing, and managing acute pancreatitis are frequently based on standards that are developed and validated in adult patients. ⋯ Although it is typically a benign disease in the pediatric population, complications such as pseudocysts may occur. When there are fatalities, they are usually attributed to systemic illness rather than the pancreatitis itself. Improvements in diagnostic and imaging methods and growing awareness cannot account for the recent increases in the observed incidence of pediatric acute pancreatitis.
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Curr Gastroenterol Rep · Oct 2007
ReviewAppropriate use of laxatives in the management of constipation.
Chronic constipation is a frequent complaint in clinical practice. It is usually amenable to laxatives, which are available with and without prescription. An overemphasis on evidence-based analysis and aggressive marketing of newly developed laxative agents has tilted the recommendations toward more expensive, but not necessarily more effective, agents. This review addresses each of the four classes of laxatives and provides suggestions about their appropriate use in clinical practice.