Biomedical sciences instrumentation
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Translational and rotational accelerations from blunt head impact can induce excessive brain strain and cause traumatic brain injuries. However, it is not clear which acceleration plays a major role in the mechanism. ⋯ Results indicated that rotational acceleration contributes more than 90% of total strain, and translational acceleration produces minimal strain. Therefore, the rotational component is a more important biomechanical metric in this study.
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The purpose of this study is to develop injury risk functions that predict zygoma fracture based on baseball type and impact velocity. Zygoma fracture strength data from published experiments were mapped with the force exerted by a baseball on the orbit as a function of ball velocity. Using a normal distribution, zygoma fracture risk functions were developed. ⋯ The experimental results validated the zygoma risk functions at the lower and upper levels. The injuries observed in the post test analysis included fractures of the zygomatic arch, frontal process and the maxilla, zygoma suture, with combinations of these creating comminuted, tripod fractures of the zygoma. Tests with a softer baseball did result in injury but these had fewer resulting zygoma bone fragments and occurred at velocities 50% higher than the major league ball.
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Commonly considered a continuum of injuries, diffuse brain injury (DBI) ranges from mild concussion to severe diffuse axonal injury. The lower end of the spectrum is generally referred to as mild traumatic brain injury (MTBI). More severe forms of DBI have garnered extensive experimentation while these milder cases are considerably less explored. ⋯ Prior experimentation estimated an angular acceleration of approximately 350 krad/s2 is necessary for the induction of mild traumatic brain injury (MTBI) in the rodent. To induce these magnitudes of angular acceleration in a repeatable manner, the impacting interface must be critically analyzed. This investigation uses a mathematical model based on parameters of a previously developed experimental model to assess the impacting interface such that angular accelerations are sufficient to produce MTBI in the rodent.
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Human modelling is an interdisciplinary research field. The topic, emotion-affected decision making, was originally a cognitive psychology issue, but is now recognized as an important research direction for both computer science and biomedical modelling. ⋯ The work is based on Ortony's theory of emotions and bounded rationality theory, and attempts to connect the emotion process with decision making. A computational emotion model is proposed, and the initial framework of this model in virtual human simulation within the platform of Virtools is presented.
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Previous research has developed a pneumatically driven device for delivering a controlled mechanical insult to cultured neurons. The neuronal cell culture was injured by applying a transient air pulse to a culture well fitted with a highly elastic Silastic culture well bottom. ⋯ The simulation results, using a finite element model of the culture well membrane, compared well with the results from the original experiments. When peak air pressure was varied from 69 kPa to 345 kPa (10 to 50 psig), numerical simulations showed that the corresponding membrane strains varied from 20 to 95% and the stress response varied from 0.5 to 1.2 MPa.