Diabetes technology & therapeutics
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Diabetes Technol. Ther. · Feb 2013
Contact heat-evoked potential stimulation for the evaluation of small nerve fiber function.
Small fiber peripheral neuropathy (SFN) is emerging as a common complication in diabetes. Currently there are few, not easily available methods of determining the integrity of small nerve fibers. This study was designed to determine the utility of a noninvasive technique, contact heat-evoked potential stimulation (CHEPS), on the identification of SFN and compare it with standardized measures of diabetic peripheral neuropathy (DPN). ⋯ This study suggests that CHEPS is a novel, noninvasive technique able to detect impairment of small nerve fiber function from skin to cerebral cortex, providing an objective measure of C and Aδ nerve dysfunction.
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Diabetes Technol. Ther. · Jan 2013
ReviewUse of microneedle array devices for continuous glucose monitoring: a review.
Microneedle array devices provide the opportunity to overcome the barrier characteristics of the outermost skin layer, the stratum corneum. This novel technology can be used as a therapeutic tool for transdermal drug delivery, including insulin, or as a diagnostic tool providing access to dermal biofluids, with subsequent analysis of its contents. ⋯ More recently, the diagnostic applications of microneedle technology have been developed. This review summarizes the existing evidence for the use of microneedle array technology as biosensors for continuous monitoring of the glucose content of interstitial fluid, focusing also on mechanics of insertion, microchannel characteristics, and safety profile.
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Diabetes Technol. Ther. · Jan 2013
Evaluation of a continuous blood glucose monitoring system using a central venous catheter with an integrated microdialysis function.
Glycemic control in critically ill patients has been the topic of an interesting debate during the last decade. An accurate continuous glucose monitoring system is essential to better understand this field. This prospective study thus evaluates the accuracy and technical feasibility of a continuous glucose monitoring system using intravascular microdialysis. ⋯ Central venous microdialysis is an accurate and reliable method for continuous blood glucose monitoring up to 48 h in patients undergoing cardiac surgery. With the microdialysis function integrated in a central venous catheter, no extra device for the continuous glucose monitoring is required. The system may be useful in critically ill patients.
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Diabetes Technol. Ther. · Jan 2013
Randomized Controlled Trial Multicenter StudyPrevalence of glucose intolerance among children and adolescents in urban South India (ORANGE-2).
This study was designed to determine the prevalence of glucose intolerance (prediabetes or diabetes) in children and adolescents in urban South India. ⋯ The prevalence of glucose intolerance is high in Asian Indian adolescents, particularly in girls with abdominal obesity.