Epilepsy & behavior : E&B
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Epilepsy & behavior : E&B · Feb 2003
Case ReportsKetamine for refractory status epilepticus: a case of possible ketamine-induced neurotoxicity.
A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days. Ketamine infusion was instituted after low-dose propofol sedation with gradual control of electrographic seizures over 72h. Reevaluation 3 months later revealed diffuse cerebellar and worsened cerebral atrophy, consistent with animal models of N-methyl-D-aspartate antagonist-mediated neurotoxicity. Animal studies of prolonged ketamine therapy are required before widespread human use in SE.
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Epilepsy & behavior : E&B · Oct 2002
Effect of Wada methodology in predicting lateralized memory impairment in pediatric epilepsy surgery candidates.
Because Wada evaluations are not standardized, it is impossible to know to what degree method variance accounts for reported differences in results. To examine this problem, three comprehensive epilepsy surgery centers compared the efficacy of two Wada memory methods to predict seizure onset laterality in 152 children being considered for epilepsy surgery. Wada memory asymmetries were evaluated using either real objects with no verbal response required or more mixed stimuli requiring a verbal response. ⋯ In contrast, Wada memory performance using mixed stimuli was worse on the side of seizure onset only among patients with seizures originating in the left-hemisphere. The superiority of real objects was most apparent in younger children with left side seizure onset. Results suggest the use of mixed stimuli is less sensitive to the effects of unilateral seizure onset, and thus, diminishes the capacity of the Wada test to predict lateralized seizure onset in children.