Zhurnal mikrobiologii, epidemiologii, i immunobiologii
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Zh. Mikrobiol. Epidemiol. Immunobiol. · Feb 1986
Historical Article[Contribution of the scientists of the 1st institute in the world in advanced training of physicians to the development of trends in preventive medicine in Russia in the prerevolutionary period (on the centenary of the founding of the Leningrad S. M. Kirov State Order of Lenin Institute of Physician Advanced Training)].
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Zh. Mikrobiol. Epidemiol. Immunobiol. · Feb 1984
[Method of determining the antilysozyme activity of microorganisms].
The method for the determination of the antilysozyme activity of microorganisms is described. The method consists in the cultivation of the strains under study in a lysozyme-containing medium, and the effect of lysozyme inactivation is determined from the growth of Micrococcus luteu S indicator strain adjacent to active strains. The quantitative evaluation of this property is presented. The study of 1 296 strains belonging to 9 genera has disclosed that antilysozyme activity occurs most frequently among Gram-negative bacteria.
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Zh. Mikrobiol. Epidemiol. Immunobiol. · May 1983
Comparative Study[IgG subclasses in chronic brucellosis patients].
The data on the levels of immunoglobulins belonging to the main classes (IgA, IgM, IgG) and IgG subclasses (IgG1, IgG2, IgG3, IgG4) in the sera of 52 patients with chronic brucellosis lasting 1-10 years are presented; in 10 of these patients immunoglobulin levels before and after vaccinal therapy are given. The blood sera of chronic brucellosis patients were found to contain IgG of 4 subclasses, the concentration of IgG1, IgG2 and IgG4 being, on the average, normal and the concentration of IgG3, elevated. A certain correlation between the increase of the IgG level and the presence of 2-mercaptoethanol-resistant specific antibodies was observed. After brucellosis patients received the injections of therapeutic vaccine, their levels of IgG and IgG1 increased, while the concentration of IgG3 decreased and that of IgG2 and IgG4 remained unchanged.
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Zh. Mikrobiol. Epidemiol. Immunobiol. · Feb 1983
[Morphological and histochemical reactions of an organism to the administration of Clostridium botulinum toxin. IX. Reactions of the neurons of the abducens nerve nucleus and of the Darkshevich's nucleus to the administration of C. botulinum type B toxin].
Pathomorphological and histochemical study carried out in guinea pigs at the stage of paralysis of the limbs after the oral administration of C. botulinum toxin has revealed the presence of morpho-metabolic changes pertaining to phase 2 of the development of dystrophic processes in the neurons of the nucleus of the abducent nerve and Darkshevich's nucleus. At the myasthenic stage the development of dystrophic processes in the neurons of Darkshevich's nucleus has been found to reach phase 3. The study indicates that C. botulinum toxin possesses different tropism in respect of the neurons of the oculomotor nuclei; this fact correlates with the clinical picture of botulism.