Japanese journal of infectious diseases
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Jpn. J. Infect. Dis. · Nov 2020
Case ReportsA Case of COVID-19 Patient with False-Negative for SARS-CoV-2 of Pharyngeal Swab, from a Chinese Traveller Returning from Wuhan, Hubei Province, China, January 2020.
We report a case of coronavirus disease (COVID-19) in a Japanese patient with a false-negative result in the reverse-transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 detection in the pharyngeal swab. The patient had acquired the infection from a Chinese traveler returning from Wuhan, Hubei Province, China. If a patient is clinically or epidemiologically suspected with COVID-19, appropriate infection and prevention control measures such as standard, contact, and droplet precaution are necessary until the patient is proven to have a true-negative result.
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Jpn. J. Infect. Dis. · Nov 2020
Comparative StudyEpidemic Characteristics of COVID-19 in Four Chinese Cities.
In December 2019, there was an outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. To date, the number of patients in China has risen to 31,000. We collected patient data from 4 Chinese cities (Hefei, Hangzhou, Wenzhou, and Shenzhen) and described epidemiologic characteristics. ⋯ Most COVID-19 patients in the 4 cities were from Wuhan originally and had spread the infection locally. Therefore, the initial stage of SARS-CoV-2 transmission in cities outside of Wuhan were mainly input. Cutting off the input and controlling the community communication could reduce local incidence.
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Jpn. J. Infect. Dis. · Nov 2020
The Potential Transmission of SARS-CoV-2 from Patients with Negative RT-PCR Swab Tests to Others: Two Related Clusters of COVID-19 Outbreak.
In December 2019, a cluster of cases of acute respiratory illness, novel coronavirus-infected pneumonia, occurred in Wuhan, Hubei Province, China. The false-negative nasopharyngeal swabs for SARS-CoV-2 caused delayed diagnosis of COVID-19, which hindered the prevention and control of the pandemic. The transmission risk of SARS-CoV-2 in negative nasopharyngeal swabs cases has rarely been addressed previously. ⋯ All recovered and were anti-SARS-CoV-2 IgG- and/or IgM-positive (100%) for serological detection of SARS-CoV-2 at the recovery stage. Our study provides a cautionary warning that negative results for nasopharyngeal swabs of suspected SARS-CoV-2 infection can increase the risk of nosocomial infection among health care providers. Serologic detection for anti-SARS-CoV-2 IgG and/or IgM is an important test in the diagnosis of COVID-19.
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Jpn. J. Infect. Dis. · Nov 2020
Risk factors analysis and nomogram construction of non-survivors in critical patients with COVID-19.
The outbreak of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, occurred in China in December 2019. This disease has caused more than 70,000 deaths worldwide. We intend to analyze the risk factors of death and establish a prognosis nomogram for critical patients with COVID-19. ⋯ Subsequently, we established a nomogram model and validated it. The sensitivity and specificity of the nomogram were 96.0% and 74.1%, respectively. The area under the curve was 0.893 (95% CI, 0.807-0.980).