Pain medicine : the official journal of the American Academy of Pain Medicine
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The application of continuous peripheral nerve block (CPNB) has been an important anesthetic tool in the management of combat soldiers wounded from current conflicts. Placing and maintaining CPNBs becomes a challenge in this patient population due to concomitant prophylactic and therapeutic anticoagulation. ⋯ This case highlights the application of simultaneous CPNB techniques in a patient with multiple extremity injuries receiving anticoagulant therapy.
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We investigated potential analgesics for chemotherapy-evoked neuropathic pain using rats treated with paclitaxel. ⋯ The present data and data from the literature review suggest that there are several potential treatments for chemotherapy-evoked neuropathic pain. Nonsteroidal anti-inflammatory drugs have little or no efficacy. Opioids have an effect, but probably only with high doses. At least some antidepressants are analgesic in these conditions. Some, but clearly not all, anticonvulsants and sodium channel blockers have efficacy. Tramadol is a particularly promising candidate. Topiramate, acetyl-L-carnitine, carbamazepine, and venlafaxine may have protective or restorative effects. Clinical trials of these candidates are needed to advance the treatment of chemotherapy-evoked pain.
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Despite a need for better physician pain management education, there are no widely accepted assessment or outcome measures to support this work. ⋯ This survey, the KnowPain-50, has good psychometric properties, correlates with clinical behaviors, and appears to distinguish between physicians with different levels of pain management expertise. It may be a useful measure of the effectiveness of physician pain management education programs.