Pain medicine : the official journal of the American Academy of Pain Medicine
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Systemic inflammation may change the bioavailability and pharmacokinetics of opioids. However, there are insufficient data on morphine pharmacokinetics in mild inflammatory conditions. This study aimed to determine the pharmacokinetics of morphine during low-dose endotoxemia in rabbits. ⋯ These findings may have important implications in patients with low-grade inflammation and imply the need to modify morphine dosing regimens to ensure optimal analgesia. The issue warrants further experimental and clinical investigation.
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Letter Case Reports
Unexpected Symptomatic Catheter Tip Mass in Chronic Intrathecal Opioid Therapy.