Pain medicine : the official journal of the American Academy of Pain Medicine
-
Randomized Controlled Trial
Evaluation of the Relative Intranasal Abuse Potential of a Hydrocodone Extended-Release Tablet Formulated with Abuse-Deterrence Technology in Nondependent, Recreational Opioid Users.
To assess the intranasal abuse potential of hydrocodone extended-release (ER) tablets developed with CIMA Abuse-Deterrence Technology compared with hydrocodone powder and hydrocodone bitartrate ER capsules (Zohydro ER, original formulation [HYD-OF]). ⋯ The statistically significant differences between hydrocodone ER vs hydrocodone powder and HYD-OF for the primary drug liking end points indicate a lower intranasal abuse potential with hydrocodone ER in healthy, nondependent, recreational opioid users.
-
Prior research indicates that older adults with knee osteoarthritis have increased sensitivity to physical activity (SPA) and respond to physical activities of stable intensity with increases in pain. Whether SPA is present in healthy older adults without chronic pain and predicts functional outcomes remains relatively unexplored. The purpose of this study was to determine the degree of SPA in healthy older adults in response to a standardized walking task, and whether SPA was associated with temporal summation of pain, pain-related fear of movement, and functional outcomes. ⋯ These findings shed light on potential mechanisms underlying SPA in older adults and suggest that SPA might be a risk factor for reduced physical activity.
-
The development of chronic postsurgical pain (CPSP) is influenced by several factors. The risk index for chronic pain (RICP) was developed to identify patients at high risk for CPSP. The aim of this study was the external validation and update of the RICP. ⋯ The study indicates external validity of the original RICP. The updated RICP also showed good predictive ability. The results are limited by the small sample size and the amount of missing outcome data.
-
Some crush-resistant tablet formulations (CRTs) reduce prescription opioid abuse by nonoral routes of administration (ROAs), especially insufflation and injection, while oral abuse increases. Oral abuse involving product manipulation vs swallowing whole for CRTs and comparators was examined. ⋯ Results suggest the need for abuse-deterrent formulations designed to reduce abuse by oral administration with product manipulation, such as chewing. Advances in this area may reduce the overall abuse of prescription opioids and interrupt the progression from abuse by swallowing whole to oral administration involving product manipulation and other ROAs.