Pain medicine : the official journal of the American Academy of Pain Medicine
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Pain Med
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Several reports in literature have identified sensitization as a possible basis for the enhanced pain reactions associated with osteoarthritis (OA). The aim of this current systematic review is to summarize functional and structural brain changes associated with surrogate sensitization parameters assessed in patients with OA-related pain. ⋯ This review shows conflicting evidence for structural and functional neuroplastic brain changes related to sensitization proxies in patients with OA.