Pain medicine : the official journal of the American Academy of Pain Medicine
The most recent articles from:
Pain Med
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We elaborated the rat hippocampi in order to assess for central nervous system changes following a peripheral neuropathic injury. ⋯ Our results showed that the peripheral nerve injury altered rat hippocampal miRNA.
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Meta Analysis Comparative Study
Comparative efficacy of oral pharmaceuticals for the treatment of chronic peripheral neuropathic pain: meta-analysis and indirect treatment comparisons.
Neuropathic pain is generally chronic and challenging to treat. Studies often ignore chronicity by reporting short-duration outcomes and fail to account for medication tolerability. We assessed efficacy of oral medications on chronic peripheral neuropathic pain. ⋯ Pregabalin and duloxetine had the largest beneficial effects for chronic peripheral neuropathic pain. In the absence of head-to-head trials, meta-analysis and indirect treatment comparisons inform best practice clinical decision-making.