Pain medicine : the official journal of the American Academy of Pain Medicine
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The block of the obturator nerve is used in pain medicine mostly for the management of acute pain after lower limb surgery or for chronic hip pain. The aim of this study was to define an injection technique based on an anatomical investigation and a magnetic resonance (MRI) analysis. ⋯ Based on the above findings, a technique of block of the obturator nerve could be defined. The method has the potential to enable an efficient and safe identification of the target nerve in clinical practice.
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Clinical Trial
Combination therapy with flupirtine and opioid: open-label case series in the treatment of neuropathic pain associated with cancer.
This study is a case series that was designed to provide data on the efficacy and the incidence and duration of adverse effects of flupirtine in the treatment of cancer-related neuropathic pain. ⋯ These results in humans follow animal studies that suggest a role for flupirtine in the treatment of neuropathic pain. This short duration open-label study in 10 subjects suggests that flupirtine may be useful in the treatment of neuropathic pain when used in combination with opioids.
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Clinical Trial
Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center.
The objective of the study was to describe the experience of methadone use in 100 consecutive chronic pain patients managed in a single multidisciplinary center. ⋯ From our experience, methadone is an effective alternative to conventional opioids for chronic pain management when used by experienced clinicians in a setting that allows for close monitoring and careful dose initiation and adjustment.
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Multicenter Study Clinical Trial
Titration with oxymorphone extended release to achieve effective long-term pain relief and improve tolerability in opioid-naive patients with moderate to severe pain.
Assess the effectiveness and tolerability of a program of gradual dose titration with oxymorphone extended release (ER) for treatment of moderate to severe chronic pain in opioid-naive patients. ⋯ Oxymorphone ER provided effective pain relief from moderate to severe chronic pain in opioid-naive patients. Gradual titration was well tolerated, with a low rate of discontinuations caused by AEs.
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Multicenter Study Clinical Trial
Cluster analysis of the pain outcomes questionnaire.
The purpose of this study was to derive and describe subtypes of Pain Outcomes Questionnaire (POQ) profiles produced by a large, heterogeneous multisite sample of chronic pain patients (N = 672). ⋯ The results of this study are generally consistent with those of previous cluster analytic investigations of pain patients and suggest that psychosocial/behavioral classification systems may serve a useful heuristic function in the assessment and treatment of chronic pain that is not provided by current diagnostic taxonomies.