São Paulo medical journal = Revista paulista de medicina
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Following hematopoietic stem cell transplantation (HSCT), karyotyping is a valuable tool for monitoring engraftment and disease status. Few studies have examined the prognostic significance of karyotypes in patients who underwent HSCT for chronic myeloid leukemia (CML). The objective of this study was to evaluate the significance of pretransplantation cytogenetic status in relation to outcomes following HSCT in CML patients. ⋯ In our study, the presence of additional abnormalities was not associated with worse outcome and relapse risk. Also, no differences in survival rates were observed. Our study supports the view that classical cytogenetic analysis remains an important tool regarding HSCT outcome.
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Pulmonary dysfunction in obese individuals may be associated with respiratory muscle impairment, and may be influenced by predominance of upper-body fat distribution. The objective of this study was to evaluate the strength of respiratory muscles in obese individuals and to analyze the influence of adipose tissue distribution. ⋯ In the obese population studied, the excess weight did not result in impairment of respiratory muscle strength, and their predominant upper-body fat distribution also did not influence respiratory muscle strength.