São Paulo medical journal = Revista paulista de medicina
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Diabetic nephropathy is a common complication of chronic kidney disease (CKD). -Inflammation in the kidneys is crucial for promoting development and progression of this complication. Wnt member 5a (Wnt5a) and secreted frizzled-related protein 5 (Sfrp5) are proinflammatory proteins associated with insulin resistance and chronic low-grade adipose tissue inflammation. ⋯ There were negative correlations between serum Sfrp5 and Wnt5a concentrations and eGFR at each stage of CKD, with higher levels in female patients. This phenomenon suggests that Sfrp5 and Wnt5a might be involved in development and evolution towards end-stage renal disease.
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Sarcopenia is a common complication in patients with cirrhosis and may lead to increased morbidity and mortality. ⋯ Sarcopenia presents high prevalence among patients with chronic liver disease, without any association with predictors of severity.
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This study was based on filling a gap in our knowledge regarding the issue of what the protective effect of physical exercise on patients within the Brazilian National Health System could be, in relation to low back pain. ⋯ High prevalence of low back pain was identified among PHU users. Physical exercise was associated as an independent protective factor against this pathological condition.
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Exposure to particulate material produced as a result of increased agricultural activity may increase the number of pneumonia hospitalizations among children. We hope to contribute to the knowledge base through highlighting the environmental mechanisms involved in this outcome and optimizing pollutant control policies. ⋯ The higher the PM2.5 level was, the greater the frequency of hospitalizations also was. Children living in peripheral areas had higher prevalence of pneumonia hospitalizations in the dry period than those who were living in the town center.
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Fatigue is a frequent symptom in patients with primary Sjögren's syndrome (pSS) and can be a cause of or be associated with sleep disorders. ⋯ The present study provides important information regarding correlations between sleep disorders and disease activity. There is a need for proper control over disease activity and for development of strategies to help patients to sleep better in order to diminish their fatigue.