São Paulo medical journal = Revista paulista de medicina
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For critically ill patients, physicians tend to administer sufficient or even excessive oxygen to maintain oxygen saturation at a high level. However, the credibility of the evidence for this practice is unclear. ⋯ It is not necessary to use liberal oxygen therapy strategies to pursue a higher level of peripheral oxygen saturation for mechanically ventilated ICU patients. Conservative oxygen therapy was not associated with any statistically significant reduction in mortality.
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Randomized Controlled Trial
A randomized clinical trial on inhaled ciclesonide for managing acute asthma in the emergency room.
Use of inhaled corticosteroids for managing acute asthma exacerbations has been tested since the 1990s. ⋯ Inhaled ciclesonide was not inferior to systemic hydrocortisone for managing acute asthma exacerbations, and it improved both clinical and spirometric parameters.
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Multicenter Study
Management strategies for implementing a multicenter cross-sectional study: lessons from the ADHERE Brazil study.
Epidemiological studies involving large samples usually face financial and operational challenges. ⋯ http://clinicaltrials.gov/ on October 10, 2013; NCT02066935.
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The legacies of colonization and of policies of forced assimilation continue to be a cause of intergenerational trauma, manifested through feelings of marginality, depression, anxiety and confusion, which place indigenous peoples at increased risk of suicide. ⋯ The study protocol is registered in the international prospective register of systematic reviews (PROSPERO); no. CRD42019141754.
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Clinical assessment of head and neck cancers is highly challenging owing to the complexity of regional anatomy and wide range of lesions. The diagnostic evaluation includes detailed physical examination, biopsy and imaging modalities for disease extent and staging. Appropriate imaging is done to enable determination of precise tumor extent and involvement of lymph nodes, and detection of distant metastases and second primary tumors. ⋯ Our study demonstrated that 18F-FDG PET/CT had higher sensitivity and accuracy for detecting head and neck malignancy, in comparison with conventional contrast-enhanced computed tomography. 18F-FDG PET/CT improved the initial staging and substantially impacted the management strategy for head and neck malignancies.