São Paulo medical journal = Revista paulista de medicina
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Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. ⋯ Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.
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Randomized Controlled Trial
A randomized clinical trial on inhaled ciclesonide for managing acute asthma in the emergency room.
Use of inhaled corticosteroids for managing acute asthma exacerbations has been tested since the 1990s. ⋯ Inhaled ciclesonide was not inferior to systemic hydrocortisone for managing acute asthma exacerbations, and it improved both clinical and spirometric parameters.
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Workplaces can be sources of mental distress. In healthcare services, this can also affect patients. ⋯ Impermanent employment contracts increased depression and burnout and reduced job satisfaction. Job satisfaction reduced poor mental health outcomes and increased safety culture. Job satisfaction and safety culture were directly proportional (one construct increased the other and vice versa), as also were depression and burnout. Better working conditions can provide a virtuous cycle of patient safety and occupational health.