São Paulo medical journal = Revista paulista de medicina
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Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission. The aim of this study was to assess the genetic diversity and prevalence of drug-resistant mutations among HIV-infected pregnant women. ⋯ The results showed that subtype B predominated, while there was low prevalence of sequences with transmitted drug resistance.
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Right ventricular (RV) dysfunction may develop over the course of chronic obstructive pulmonary disease (COPD) and is an important predictor of morbidity and mortality. Polymorphism of the multidrug resistance-1 (MDR-1) gene has been correlated with worse clinical findings among patients with COPD. Our aim here was to investigate the relationship between MDR-1 C3435T gene polymorphism and RV dysfunction in COPD patients. ⋯ MDR-1 C3435T gene polymorphism was associated with RV dysfunction in patients with COPD.
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Observational Study
Foot health and quality of life among university students: cross-sectional study.
Foot problems are believed to reduce quality of life and are increasingly present. Even among young adults of university age, untreated foot problems can lead to postural and mobility problems. Accordingly, our aim here was to determine the relationship between foot health and quality of life and general health among male and female university students. ⋯ These university students' quality of life relating to foot health was poor. This appears to be associated with the university period, regardless of gender.
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Case Reports
Bariatric surgery in individuals with severe cognitive impairment: report of two cases.
Bariatric surgery has become the gold-standard treatment for refractory morbid obesity. Obesity is frequently associated with certain syndromes that include coexisting cognitive deficits. However, the outcomes from bariatric surgery in this group of individuals remain incompletely determined. ⋯ Bariatric surgery among individuals with intellectual impairment is a controversial topic. There is a tendency among these individuals to present significant weight loss and comorbidity control, but less than what is observed in the general obese population. The severity of the intellectual impairment may be taken into consideration in the decision-making process regarding the most appropriate surgical technique. Bariatric surgery is feasible and safe among these individuals, but further research is necessary to deepen these observations.
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Review Case Reports
Report of a rare case and review of adult intestinal duplication at the opposite side of mesenteric margin.
To study the previously discovered clinical entity of adult intestinal duplication and its treatment, and propose an extension to its existing classification. ⋯ Adult intestinal duplication is quite rare. Its clinical manifestations are nonspecific. From this finding of intestinal duplication originating at the opposite side of the mesenteric margin, a further extension of the existing anatomical classification is proposed.