Gastroenterology and hepatology from bed to bench
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Dong Y, Qi B, Feng XY, Jiang CM. Meta-analysis of Barrett's esophagus in China. World J Gastroenterol 2013;19(46):8770-8779 The disease pattern of Barrett's esophagus (BE) in China is poorly characterised particularly in comparison with other developed countries. ⋯ Contrary to previous data, this study found progenitor cells widely distributed in human esophageal tissue and included already differentiated epithelial cells. This insight into esophageal homeostasis may inform future studies exploring the pathological mechanisms underpinning homeostatic disruption in disease states such as Barrett's esophagus. Papers were prepared by: Drs Ishfaq Ahmad and Luke Materacki, Department of Medicine, Alexandra Hospital, Redditch, UK.
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Gastroenterol Hepatol Bed Bench · Jan 2013
Case ReportsA 63 years old woman with progressive mechanical dysphagia and weight loss: a case presentation.
When considering a patient with dysphagia, an attempt should be made to determine whether the patient has difficulty only with solid boluses (suggestive of mechanical dysphagia) or with liquids and solids (suggestive of a motility dysphagia). Lesions such as an oesophageal tumor and external pressure effect from a lung tumor or aberrant vessel can lead to mechanical dysphagia. ⋯ There were no respiratory symptoms. Diagnosis was made by a computerized tomography scan of the thorax, bronchoscopy and bronchial biopsy.
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Gastroenterol Hepatol Bed Bench · Jan 2012
How to control confounding effects by statistical analysis.
A Confounder is a variable whose presence affects the variables being studied so that the results do not reflect the actual relationship. There are various ways to exclude or control confounding variables including Randomization, Restriction and Matching. ⋯ When experimental designs are premature, impractical, or impossible, researchers must rely on statistical methods to adjust for potentially confounding effects. These Statistical models (especially regression models) are flexible to eliminate the effects of confounders.
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Gastroenterol Hepatol Bed Bench · Jan 2011
Dubin-Johnson syndrome presenting after acute viral hepatitis.
Elevated serum level of bilirubin is a common manifestation which is occurred in several diseases. Hyperbilirubinemia can manifest either conjugated or unconjugated. ⋯ Merely conjugated hyperbilirubinemia is the main manifestation of two congenital syndromes, including Dubin-Johnson and rotor syndrome; however it can be seen in some patients with recurrent benign intrahepatic cholestasis. This article reports a patient with Dubin- Johuson syndrome as a benign and rare condition.