Tumori
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At the beginning of the 80's the Italian Group for Clinical Research (G. O. I. ⋯ Today, the interest of the Group is concentrated in studying the optimal antiemetic prophylaxis for delayed emesis induced by moderately emetogenic chemotherapy. The rules always followed by the Italian Group for Antiemetic Research are: --complete independence of judgement on the efficacy and the tolerability of antiemetic drugs from the pharmaceutical companies; --priority of ethical problems in designing clinical trials; --strict adherence to the methodological problems of antiemetic research and--complete autonomy concerning the study planned, the data computerization and the data elaboration. In the last twelve years approximately 70 Italian centres have enrolled their patients into the studies of the Italian Group for Antiemetic Research.
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Anemia is common in cancer patients, especially in those with more advanced stages of progressive tumor growth, the frequency varying on type of cancer, stage and chemotherapy or radiation therapy used. The pathophysiology is multifactorial. However the most common anemia is the anemia whose features are similar to those seen in other chronic diseases (anemia of chronic disease--ACD). ⋯ No significant adverse effects of rHuEPO administration have been reported in any of the studies published to date. It can be concluded that rHuEPO therapy may be safe and effective in selected surgical patients, in stimulating erythropoiesis, in expanding the circulating RBCs mass, in increasing the volume of AB that can be collected pre-operatively and, consequently, in reducing the exposure to homologous blood. Therapy with rHuEPO may prove to be a useful addition to existing strategies of blood conservation to minimize exposure to HB.
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Review Case Reports
Radiation-induced sarcoma following curative radiotherapy for testicular seminoma: case report and brief review of the literature.
We report a case of radiation-induced retroperitoneal leiomyosarcoma which developed 37 years after the patient received radiation therapy for testicular seminoma. The sarcoma originated within the para-aortic field, extensively involving neighboring organs, soft tissue and muscle tissues, and could be only partially resected. The absolute number of these secondary sarcomas is low, but the risk of developing such neoplasms calls for awareness in the long-term follow-up of cured seminoma patients.