The cancer journal
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Multicenter Study Clinical Trial
Preoperative therapy with concurrent paclitaxel/carboplatin/infusional 5-FU and radiation therapy in locoregional esophageal cancer: final results of a Minnie Pearl Cancer Research Network phase II trial.
This phase II study was designed to determine the feasibility, toxicity, and therapeutic efficacy of a novel outpatient combined-modality preoperative regimen in patients with localized esophageal cancer. ⋯ This novel combined-modality regimen is highly active in the treatment of locoregional esophageal cancer, producing an actuarial 3-year survival of 41%. Although this preoperative regimen produced moderate acute toxicity, there were no treatment-related deaths and the large majority of patients were able to undergo subsequent esophageal resection. These results, obtained in a community-based setting and involving multiple surgeons, radiation oncologists, and medical oncologists, compare favorably with those of previous single-center and multicenter results. Further evaluation of novel combined-modality programs is warranted, as is the incorporation of epidermal growth factor receptor antagonists or other targeted agents.
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The use of intraoperative imaging (IOI) in neurosurgical practice is proving to be yet another important advance in the evolution of brain tumor resection, particularly for the most common adult primary brain tumor--glioblastoma (GBM). The number of surgeons using IOI continues to increase, and the experience to date affords an opportunity to assess the value of the various techniques used for IOI.
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Surgical resection is a critical aspect of the management of a patient with a glioblastoma (GBM). An intimate knowledge of the anatomy of a GBM, as well as familiarity with particular surgical techniques and adjunctive technologies is required for safe surgical resection. The goals of resection include diagnosis, relief of mass effect, and cytoreduction. ⋯ Even in functionally critical areas, "gross total" resections are possible if proper techniques are employed. It is recommended that a "gross total" resection of the enhancing portion of a GBM be performed whenever possible. With this philosophy, the mortality rate is 3% and the rate of major neurologic morbidity is less than 10%.
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Locoregional treatment for adult soft tissue sarcomas of the head and neck: an institutional review.
The purpose of this study was to review treatment results for primary soft tissue sarcomas of the head and neck in order to determine prognostic factors. ⋯ Multimodality therapy with both surgery and radiotherapy improves local control, particularly in patients with close or positive surgical margins. Aggressive attempts at salvage therapy for locoregional failures are warranted and frequently produce long-term disease control.
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Stage T1c prostate cancer is defined as nonpalpable disease diagnosed by needle biopsy. As more patients are being diagnosed early because of prostate-specific antigen (PSA) screening, the distribution of patients by stage has shifted dramatically. Although this group has traditionally been characterized as having early-stage disease and the best prognosis, on review of these patients, we instead found a very heterogeneous group with a wide spectrum of outcomes that depend on both patient (Gleason grade and pretreatment PSA) and treatment (dose) factors. ⋯ Contrary to general assumption, stage T1c prostate cancer is composed of a very heterogeneous group of patients with varying outcomes. When treatment modalities and institutional data are evaluated, the spectrum of disease must be accounted for by additional prognostic factors and subset analysis. Improvement in prostate imaging and multiple core biopsies may be helpful in better defining the extent of disease in the individual patient.