Veterinary anaesthesia and analgesia
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Controlled Clinical Trial
Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies.
To investigate the effect of plasma concentrations obtained by a low dose constant rate infusion (CRI) of racemic ketamine or S-ketamine on the nociceptive withdrawal reflex (NWR) in standing ponies. ⋯ Antinociceptive activity in standing ponies, demonstrated as a depression of the NWR, could only be detected after treatment with racemic ketamine. S-ketamine may have lacked this effect as a result of lower plasma concentrations, a more rapid metabolism or a lower potency of S-ketamine in Equidae so further investigation is necessary.
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Randomized Controlled Trial
A comparison of recovery times and characteristics with sevoflurane and isoflurane anaesthesia in horses undergoing magnetic resonance imaging.
To compare recovery times and quality following maintenance of anaesthesia with sevoflurane or isoflurane after a standard intravenous induction technique in horses undergoing magnetic resonance imaging (MRI). ⋯ No differences in recovery times or quality were detected following isoflurane or sevoflurane anaesthesia after intravenous induction. Clinical relevance Sevoflurane affords no obvious advantage in recovery over isoflurane following a standard intravenous induction technique in horses not undergoing surgery.
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Randomized Controlled Trial
The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs.
To investigate the influence of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and reduction in pulse rate (PR) in dogs. ⋯ The clinical safety of alpha2-adrenoceptor agonists could be markedly improved with less peripheral cardiovascular effects.
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Clinical Trial
Development of a technique for continuous perineural blockade of the palmar nerves in the distal equine thoracic limb.
To develop a technique for placing continuous peripheral nerve block (CPNB) catheters adjacent to palmar nerves in horses and to evaluate the effect of low-volume local anesthetic (LA) infusion on nociception in the distal equine thoracic limb. ⋯ Continuous perineural LA infusion along palmar nerves may develop into an effective analgesic technique in horses suffering from lower limb pain.
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Randomized Controlled Trial
The effects of medetomidine on the action of vecuronium in dogs anaesthetized with halothane and nitrous oxide.
To quantify the effects of medetomidine on the onset and duration of vecuronium-induced neuromuscular blockade in dogs. ⋯ Medetomidine 5 microg kg(-1) as pre-anaesthetic medication shortened the duration of effect of vecuronium in halothane-anaesthetized dogs and accelerated recovery, but did not affect the onset time. These changes are of limited clinical significance.