The lancet oncology
-
The lancet oncology · Aug 2020
Randomized Controlled Trial Multicenter StudyPathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial.
Outcomes for children and adults with advanced soft tissue sarcoma are poor with traditional therapy. We investigated whether the addition of pazopanib to preoperative chemoradiotherapy would improve pathological near complete response rate compared with chemoradiotherapy alone. ⋯ National Institutes of Health, St Baldrick's Foundation, Seattle Children's Foundation.