The lancet oncology
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The lancet oncology · Jul 2022
Randomized Controlled Trial Multicenter StudyFulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial.
Capivasertib, an AKT inhibitor, added to fulvestrant, was previously reported to improve progression-free survival in women with aromatase inhibitor-resistant oestrogen receptor (ER)-positive, HER2-negative advanced breast cancer. The benefit appeared to be independent of the phosphoinositide 3-kinase (PI3K)/AKT/phosphatase and tensin homologue (PTEN) pathway alteration status of tumours, as ascertained using assays available at the time. Here, we report updated progression-free survival and overall survival results, and a prespecified examination of the effect of PI3K/AKT/PTEN pathway alterations identified by an expanded genetic testing panel on treatment outcomes. ⋯ AstraZeneca and Cancer Research UK.
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The lancet oncology · Jul 2022
Association of tobacco control measures with the intention to quit tobacco consumption: a cross-sectional study from India.
More than 7 million cancer-related deaths worldwide are associated with tobacco, of which India is the second largest producer and consumer. The current study tests a model based on the hypothesis that poor implementation of tobacco control measures and poor basic education affect the frequency and duration of tobacco use, creating substantial nicotine dependency and thereby preventing smokers from quitting tobacco consumption. ⋯ None.
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The lancet oncology · Jul 2022
Current public perception of, and barriers to, palliative care in China: a mixed-methods study.
Cancer is a major cause of death in China, accounting for 2·56 million deaths in the country in 2018 alone. Yet, on that year, only 28 600 patients (1·1%) at the end of life received palliative care. Existing studies in palliative care have mainly been done in medical environments. The aim of this study was to focus instead on the general public and to identify the public's perceptions of, and demand for, various palliative care services, as well as barriers to palliative care in China. ⋯ Ministry of Education of China, Youth Project of Humanities and Social Sciences (project number 20XJC840001); China Postdoctoral Science Foundation (project number 2021M691521); and 2020 Young Teacher Development Project of the Chinese Universities Scientific Fund (project number 230600001002020030).