The lancet oncology
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The lancet oncology · Dec 2024
Deep learning using histological images for gene mutation prediction in lung cancer: a multicentre retrospective study.
Accurate detection of driver gene mutations is crucial for treatment planning and predicting prognosis for patients with lung cancer. Conventional genomic testing requires high-quality tissue samples and is time-consuming and resource-consuming, and as a result, is not available for most patients, especially those in low-resource settings. We aimed to develop an annotation-free Deep learning-enabled artificial intelligence method to predict GEne Mutations (DeepGEM) from routinely acquired histological slides. ⋯ For the Chinese translation of the abstract see Supplementary Materials section.