The lancet oncology
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The lancet oncology · Aug 2014
ReviewTranslational implications of somatic genomics in acute myeloid leukaemia.
Acute myeloid leukaemia (AML) is caused by acquired somatic mutations in haemopoietic progenitors. Understanding of the genetic basis of the disease has greatly benefited from the use of DNA sequencing to identify novel disease alleles. Chromosomal aberrations are known to drive AML and are the mainstay of risk classification. ⋯ Comprehensive next-generation sequencing studies have given insight into AML pathogenesis. These insights are leading to refined prognostic stratification and suggest differentially tailored treatment based on integrated genetic profiles. Translation of comprehensive genetic analyses to the clinical setting is the next challenge, to enable genotype-specific therapies for patients with AML and other malignant disorders.
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The lancet oncology · Aug 2014
Multicenter Study Observational StudySurvival for haematological malignancies in Europe between 1997 and 2008 by region and age: results of EUROCARE-5, a population-based study.
More effective treatments have become available for haematological malignancies from the early 2000s, but few large-scale population-based studies have investigated their effect on survival. Using EUROCARE data, and HAEMACARE morphological groupings, we aimed to estimate time trends in population-based survival for 11 lymphoid and myeloid malignancies in 20 European countries, by region and age. ⋯ Compagnia di San Paolo, Fondazione Cariplo, European Commission, and Italian Ministry of Health.
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The lancet oncology · Aug 2014
Randomized Controlled Trial Multicenter StudyMEK1/2 inhibition delays progression of uveal melanoma.
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The lancet oncology · Aug 2014
Randomized Controlled Trial Comparative StudyMethylprednisolone in patients with cancer using opioids.