The lancet oncology
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The lancet oncology · Apr 2014
Multicenter StudyClinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data.
We aimed to assess the clinical validity of circulating tumour cell (CTC) quantification for prognostication of patients with metastatic breast cancer by undertaking a pooled analysis of individual patient data. ⋯ Janssen Diagnostics, the Nuovo-Soldati foundation for cancer research.
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The lancet oncology · Apr 2014
Randomized Controlled Trial Comparative StudyRituximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial.
Patients with advanced-stage, low-tumour-burden follicular lymphoma have conventionally undergone watchful waiting until disease progression. We assessed whether rituximab use could delay the need for chemotherapy or radiotherapy compared with watchful waiting and the effect of this strategy on quality of life (QoL). ⋯ Cancer Research UK, Lymphoma Research Trust, Lymphoma Association, and Roche.
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Renal-cell carcinoma is considered to be a radioresistant tumour, but this notion might be wrong. If given in a few (even single) fractions, but at a high fraction dose, stereotactic body radiotherapy becomes increasingly important in the management of renal-cell carcinoma, both in primary settings and in treatment of oligometastatic disease. ⋯ This effect, caused by immunological processes, might be enhanced when targeted drugs and stereotactic body radiotherapy are combined. Therefore, rigorous, prospective randomised trials involving a multidisciplinary scientific panel are needed urgently.
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The lancet oncology · Apr 2014
Webcasts Observational StudyAssociation between developmental steps in the organogenesis of the uterine cervix and locoregional progression of cervical cancer: a prospective clinicopathological analysis.
Our previous work provided evidence that early cervical cancer is locally confined to the Müllerian compartment that develops in women from the embryonic paramesonephric-mesonephric complex. We aimed to investigate if the concept of tumour permeation within ontogenetic domains is also valid for tumour progression and advanced disease. ⋯ University of Leipzig and Leipzig School of Radical Pelvic Surgery.