The lancet oncology
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Lancet Oncol.
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The lancet oncology · Feb 2011
A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment.
Neoadjuvant chemotherapy before cystectomy confers a survival benefit in bladder cancer, but it has not been widely adopted since most patients do not benefit and we are at present unable to predict those that do. Since the most important predictor of recurrence after cystectomy is pathologically positive nodes, our aim was to assess techniques that define this stage for the selection of patients for neoadjuvant chemotherapy. ⋯ US National Cancer Institute (R01CA143971).