The lancet oncology
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Penile cancer is a rare malignancy affecting more than 400 men per year in the UK. Studies on the aetiopathogenesis of this cancer have focused on its association with the human papilloma virus; however, there have also been several studies on the genetic and molecular changes that occur. ⋯ We review this process, and assess the independent genetic events that occur in penile cancer. Knowledge of this cancer is progressing slowly and could be furthered by multicentre cooperation and the formation of national tumour banks, which will aid the development of novel therapeutic agents to reduce the morbidity and mortality of penile cancer.
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The lancet oncology · Apr 2007
A newly devised scoring system for prediction of mortality in patients with colorectal cancer: a prospective study.
Postoperative morbidity and mortality from colorectal cancer varies widely across hospitals in the UK. We aimed to assess whether a newly developed score from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) could predict mortality from colorectal cancer surgery as accurately as the Physiology and Operative Severity Score for enUmeration of Mortality and morbidity (POSSUM), Portsmouth POSSUM (P-POSSUM), or the ColoRectal POSSUM (CR-POSSUM). ⋯ POSSUM overpredicted mortality, whereas P-POSSUM underpredicted mortality from colorectal-cancer surgery. CR-POSSUM was a more-accurate predictor of mortality in most analyses than was POSSUM and P-POSSUM. Although CR-POSSUM gave the closest prediction of overall mortality, analyses of subgroups of patients showed that ACPGBI score predicted overall mortality most accurately.